HPE ProLiant DL380 Gen11
The versatile 2U workhorse for virtualization, analytics, and hybrid cloud
Overview
The HPE ProLiant DL380 Gen11 is a dual-socket 2U rack server built to take on a broad mix of demanding workloads without forcing you to overbuy. It pairs 4th and 5th Gen Intel Xeon Scalable processors with deep DDR5 memory, PCIe Gen5 expansion, and dense EDSFF storage, so it scales cleanly as data and traffic grow. With room for multiple GPUs it also handles graphics-heavy tasks and lighter AI inference alongside everyday business apps. iLO 6 security and HPE Compute Ops Management give you a cloud-style operating experience from a single console.

Why HPE ProLiant DL380 Gen11
Built for mixed enterprise workloads
A balanced 2U design handles virtualization, software-defined storage, databases, and video transcoding on one platform, so it adapts as your needs shift instead of locking you into one job.
Scales deep on memory and I/O
Up to 8 TB of DDR5 across 16 DIMMs per socket plus PCIe Gen5 expansion keeps memory-hungry and bandwidth-heavy applications responsive at peak load.
GPU acceleration when you need it
Room for up to three double-wide or four single-wide GPUs lets you speed up graphics-intensive work and AI inference without adding a separate system.
Security rooted in silicon
iLO 6 with HPE's Silicon Root of Trust protects firmware across the server's life, so the platform stays trustworthy from boot through decommission.
Run it cool and dense
Air cooling and direct liquid cooling options let you push high-TDP processors hard while keeping power and thermals in check.
Manage from anywhere
HPE Compute Ops Management gives you cloud-based monitoring, updates, and automation, so a distributed fleet feels like one system.
At a glance
- Form factor
- 2U rack, dual-socket (2P)
- Processors
- 4th and 5th Gen Intel Xeon Scalable, up to 64 cores per CPU
- Max memory
- Up to 8 TB DDR5 (16 DIMMs per processor, up to 5600 MHz)
- GPU support
- Up to 3 double-wide or 4 single-wide GPUs
- Storage
- LFF, SFF, and up to 20 EDSFF NVMe drives
- Expansion
- PCIe Gen5 I/O
- Cooling
- Air-cooled and direct liquid cooling
- Management
- HPE iLO 6, HPE Compute Ops Management
Where it fits
Frequently asked
What workloads is the DL380 Gen11 best suited for?
It is a general-purpose 2U server tuned for mixed enterprise workloads, including virtualization, software-defined storage, databases, VDI, and video transcoding. The balance of compute, memory, and I/O makes it a safe default for hybrid cloud environments.
How much memory and storage can it hold?
It supports up to 8 TB of DDR5 memory with 16 DIMMs per processor, and a flexible drive bay design that takes LFF, SFF, and up to 20 EDSFF NVMe drives.
Can the DL380 Gen11 run GPUs for AI?
Yes. It supports up to three double-wide or four single-wide GPUs, which is enough to accelerate graphics-heavy work and AI inference running alongside your everyday applications.
How is the server managed and secured?
HPE iLO 6 provides secure server-level control with a Silicon Root of Trust, and HPE Compute Ops Management adds a cloud console to monitor and update servers across sites from one place.
Build your HPE bill of materials.
Send us the requirement, the project, or an existing quote to beat. We come back with a validated, TAA-compliant HPE configuration and a real price, often below list.
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